Probably, shortly before the start of work at the College del Cambio, in 1496 Perugino performed one of his best monumental works – the Crucifix fresco triptych. It consists of three, divided by columns and pilasters and inscribed in the arched framing of compositions: central – Crucifixion with Mary Magdalene and two side – Madonna with Saint Bernard and John the Theologian with Saint Jerome.
Lack of these three scenes, their austere simplicity, breadth and unobtrusive beauty, muted colors, a very generalized landscape panorama, sparseness of the composition, built on pauses, which creates a mood of awe of silence, make a striking contrast to the murals of College del Cambio and show the breadth of Perugino’s range of creativity.