The paintings depicting the grieving Virgin were popular religious images.
This grieving mother with outstretched hands was painted in 1553-54, as a copy of the detail of the painting “Xie Man”, which Titian painted for the emperor in 1548. She was commissioned by Maria of Hungary, the eldest sister of Emperor Charles V.
Related Paintings 
Ascension of the Mother of God (Assunta) by Titian Vecellio 
A miracle with a talking newborn who removes from his mother an accusation of adultery by Titian Vecellio 
Healing of an angry son by Titian Vecellio 
Caesar’s Dinar by Titian Vecellio 
Portrait of Paul III by Titian Vecellio 
Portrait of Isabella of Portugal by Titian Vecellio 
Danae by Titian Vecellio 
Portrait of Ranucho Farnese by Titian Vecellio
Ascension of the Mother of God (Assunta) by Titian Vecellio A miracle with a talking newborn who removes from his mother an accusation of adultery by Titian Vecellio Healing of an angry son by Titian Vecellio Caesar’s Dinar by Titian Vecellio Portrait of Paul III by Titian Vecellio Portrait of Isabella of Portugal by Titian Vecellio Danae by Titian Vecellio Portrait of Ranucho Farnese by Titian Vecellio